Yes, I am using the ME2 for boost control via a Mac solenoid (the same type as branded AEM, Haltech, etc and sold for 3 times their value!) and it works very well. The "fast spool" mode allows you to set a percentage of target boost, below which the solenoid remains energised (maximum bleed off) to prevent any wastegate movement. Once boost rises above the set percentage it starts to modulate the solenoid at the initial duty cycle value. If you set the percentage too high you can easily overshoot the target, so I guess it's effective if you find a good balance.
Boost is mapped at 1000RPM increments, with each range having a target boost and duty cycle setting. There's a third field that the ME2 populates itself for reference, and that's calculated duty. You can approximate duty cycle during the initial setup, then go out for a run. The ME2 will then calculate, based on the boost levels achieved, very close to the required duty cycle for your target boost. If boost goes over target, the ME2 will reduce duty cycle at the rate specified in "gain" until target boost is reached, then write that value to calculated duty. Subsequent control will then remain based on the new value.
I am using an Innovate LC-1 wideband. Excellent value product but it can be finicky. Have a look at the Innovate forums for details of many problems with these units. I should add though, mine has always worked fine, and the latest (still beta) firmware seems to have addressed most issues.
Yes, I am using the RPM switch to control T-VIS, but I should note that the ME2 output needs to be inverted (easily done with a NC relay) to work correctly.
I have also (partially) retained the factory ECU's boost and T-VIS control. For boost, I have the factory ECU output energising a relay which then connects the ME2 to the boost control solenoid - this allows the factory ECU to still limit boost to spring pressure when necessary, ie during warm-up and with low octane fuel. For T-VIS, I've connected a NC relay energised by the ME2 RPM switch, which then disconnects the T-VIS solenoid from the factory ECU. This allows the ME2 to always ensure T-VIS is open above its set point, but give the factory ECU control below it. Toyota programmed the factory ECU to open T-VIS below the trigger point at light loads, and also as a torque limiting function with low octane fuel.
One of the key advantages of using a piggyback system is that you can retain the protective functions of the factory ECU, so I wanted to ensure that this was the case with my install. It's actually possible to significantly increase engine power using an ME2, without defeating ANY of the factory safeguards - if you tune too aggressively, the factory ECU will soon pull you up!