Good question..
The primary load sensor, either AFM or MAP won't make any difference as there's no change to metered air flow, it's all happening in the combustion chamber.
Any engine that's knock limited will show some benefit, but more so forced induction or high compression engines. The reason it works so well on a 3SGTE is because of the stock ECU timing curve making the engine excessively knock limited on ULP98, and also the dual Ign/EFI adjustment strategy when low level knock is detected by the ECU.. ie adding fuel and reducing advance. Take away the knock, and it simply doesn't happen. On top of that the ECU also adds fuel to limit thermal efficiency (edit), and reduce combustion temps.
So you can see where the gains are, so any similarly designed management system would see a similar level of performance gains.
As for being E proof, things aren't quite so clear. There's been a systematic attemp to 'future proof' cars over a number of years with ethanol being an ever present certainty, but unknown implementation date, no doubt to make older cars backwards compatible with ethanol enhanced fuel, and newer ones compatible with higher levels of E, which is already on the table (E15/E25). What level is safe, and what level will cause problems? no idea.
You can only go on reliable results from actual users as most concerns seem to be unfounded. When you look at cars, including 2's, that have been converted to E85 and have been running without major issues for several years on basically stock fuel systems, you get some insight into what are real issues and what's not.
Your already running E in your ULP98 (5%), in the US 94 (10%), and soon you just won't have any option but 10% in anything. Trouble is with pump fuel the MON and O2 content is mandated and capped. Suppliers use the E content to raise the RON rating back to the advertised level, so basically 98 + 5%E is still 98, same as they've done with 91 E10. On top of that, blending by the suppliers instead of the oil refineries is a worry as who's to say the E content isn't likely to exceed 10% (there's money in E).
At this point in time, splash blending E85 into ULP98 avoids most of the issues, but down the track things don't look quite so straight forward..one thing is for sure, E is here to stay.