I dont think it would be a major issue. If your running a minimum, say 10% on a stock ECU to get to around the 100RON level, and the bio-flex drops off a few percent, it would simply mean the ECU would be back to trimming the JDM ign timing. Anything greater than 10% would put you over 100RON by a reasonable margin, so there shouldn't be enough variation to cause any issue.
With a tuned ECU, I doubt you'd want to run as low as 10% given the performance gains available..there's a real tendency to get greedy with this stuff where thats concerned. With higher mixes AFR's become the key indicator for safe tuning, as knock just doesn't take place on a healthy engine. Personally, I'd stay away from GM sensors for that reason, and stick with the OEM, and tune conservatively.
If your concerned about the possible effects of the E on the stock pump or hoses etc., I'd look at 15-20% in that case, which from all reports seems to have low impact.