The problem with aftermarket wheels for MR2's is not stud pattern but the need to find a staggered set.
The Nissan GTST and GTR 16" have large tapered centers and neither will fit the Toyota hub spiggot, so something needs to be done about that. Someone else on here may know if metal hub rings are available.
Apart from centering, the offset/width on the front is important if you want good shake free steering with no tramlining.
The GTST wheels have a 40mm offset that is close to stock (45), so the scrub radius is not changed much, and at 6.5" they are not much wider than stock (6")
Also apart from looks, with 16's you need to think about tyre availability.
The fronts are no problem, but the rear choice is limited in a 225/45R16 if you want to retain the stock rolling diameter.
FYI, if you were to use a 225/50R16 on the GTR rear (larger rolling diameter than OEM) with a lowered suspension it will probably rub on bumps, so guard rolling needed.
EDIT
I just found a pic of the Nissan GTST/GTR combo to give you an idea of what they look like. The car has been lowered about 1.5"